一氧化氮参与血管生成的调节。
Nitric oxide is involved in the regulation of angiogenesis.
作者信息
Pipili-Synetos E, Sakkoula E, Maragoudakis M E
机构信息
Department of Pharmacology, Medical School, University of Patras, Greece.
出版信息
Br J Pharmacol. 1993 Apr;108(4):855-7. doi: 10.1111/j.1476-5381.1993.tb13476.x.
Abstract
The in vivo model of the chick embryo chorioallantoic membrane (CAM) was used to study the involvement of nitric oxide (NO) in angiogenesis. The nitrovasodilator sodium nitroprusside (NaNP) and the amino acid, L-arginine, inhibited angiogenesis, assessed as both collagenous protein biosynthesis and vascular density. NG-monomethyl-L-arginine (L-NMMA), an NO synthase inhibitor, increased both collagenous protein biosynthesis and vascular density, indicating that this agent promotes angiogenesis. These results suggest that NO may participate in the regulation of angiogenesis. Manipulation of NO synthesis therefore, may prove to be another approach for controlling angioproliferative diseases.
摘要
采用鸡胚绒毛尿囊膜（CAM）的体内模型来研究一氧化氮（NO）在血管生成中的作用。硝血管扩张剂硝普钠（NaNP）和氨基酸L-精氨酸抑制血管生成，这通过胶原蛋白生物合成和血管密度来评估。NO合酶抑制剂NG-单甲基-L-精氨酸（L-NMMA）增加了胶原蛋白生物合成和血管密度，表明该药物促进血管生成。这些结果表明，NO可能参与血管生成的调节。因此，操纵NO合成可能被证明是控制血管增殖性疾病的另一种方法。
相似文献
1
Nitric oxide is involved in the regulation of angiogenesis.一氧化氮参与血管生成的调节。
Br J Pharmacol. 1993 Apr;108(4):855-7. doi: 10.1111/j.1476-5381.1993.tb13476.x.
2
Evidence that nitric oxide is an endogenous antiangiogenic mediator.一氧化氮是内源性抗血管生成介质的证据。
Br J Pharmacol. 1994 Mar;111(3):894-902. doi: 10.1111/j.1476-5381.1994.tb14822.x.
3
In vivo experimental evidence that the nitric oxide pathway is involved in the X-ray-induced antiangiogenicity.体内实验证据表明一氧化氮途径参与了X射线诱导的抗血管生成作用。
Br J Cancer. 1996 Dec;74(12):1916-23. doi: 10.1038/bjc.1996.653.
4
Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.一氧化氮在体内介导血管生成，且在体外介导由P物质促进的内皮细胞生长和迁移。
J Clin Invest. 1994 Nov;94(5):2036-44. doi: 10.1172/JCI117557.
5
Irradiation dose-response effects on angiogenesis and involvement of nitric oxide.辐射剂量对血管生成的反应效应及一氧化氮的参与
Anticancer Res. 2005 Mar-Apr;25(2A):1059-65.
6
Involvement of nitric oxide in the inhibition of angiogenesis by interleukin-2.一氧化氮参与白细胞介素-2对血管生成的抑制作用。
Br J Pharmacol. 1997 Nov;122(5):793-5. doi: 10.1038/sj.bjp.0701436.
7
The effect of inhibitors of the L-arginine/nitric oxide pathway on endotoxin-induced loss of vascular responsiveness in anaesthetized rats.L-精氨酸/一氧化氮途径抑制剂对麻醉大鼠内毒素诱导的血管反应性丧失的影响。
Br J Pharmacol. 1991 May;103(1):1218-24. doi: 10.1111/j.1476-5381.1991.tb12327.x.
8
Nitric oxide and the collagenous protein biosynthesis of irradiated chick chorioallantoic membrane.一氧化氮与辐照鸡胚绒毛尿囊膜的胶原蛋白生物合成
J BUON. 2008 Jan-Mar;13(1):87-91.
9
Influence of SIN-1 and sodium nitroprusside (NANP) on ox-LDL metabolism in macrophages.SIN-1和硝普钠（NANP）对巨噬细胞中氧化型低密度脂蛋白（ox-LDL）代谢的影响。
J Physiol Pharmacol. 1994 Sep;45(3):387-97.
10
Endothelium-dependent relaxation and noradrenaline sensitivity in mesenteric resistance arteries of streptozotocin-induced diabetic rats.链脲佐菌素诱导的糖尿病大鼠肠系膜阻力动脉的内皮依赖性舒张和去甲肾上腺素敏感性
Br J Pharmacol. 1992 Oct;107(2):393-9. doi: 10.1111/j.1476-5381.1992.tb12757.x.
引用本文的文献
1
Repurposing of modafinil as an anti-inflammatory drug: a systematic review of experimental studies.将莫达非尼重新用作抗炎药物：实验研究的系统评价
Naunyn Schmiedebergs Arch Pharmacol. 2025 May 13. doi: 10.1007/s00210-025-03964-9.
2
The Triple Crown: NO, CO, and HS in cancer cell biology.三重冠：癌症细胞生物学中的 NO、CO 和 HS。
Pharmacol Ther. 2023 Sep;249:108502. doi: 10.1016/j.pharmthera.2023.108502. Epub 2023 Jul 28.
3
Electronic structure and mechanism for the uptake of nitric oxide by the Ru(iii) antitumor complex NAMI-A.钌（III）抗肿瘤配合物NAMI - A对一氧化氮的摄取的电子结构及机制
RSC Adv. 2021 Feb 15;11(13):7381-7390. doi: 10.1039/d0ra10622d. eCollection 2021 Feb 10.
4
Hypercholesterolemia and Lymphatic Defects: The Chicken or the Egg?高胆固醇血症与淋巴系统缺陷：孰因孰果？
Front Cardiovasc Med. 2021 Jun 23;8:701229. doi: 10.3389/fcvm.2021.701229. eCollection 2021.
5
CDC-derived extracellular vesicles reprogram inflammatory macrophages to an arginase 1-dependent proangiogenic phenotype.CDC 衍生的细胞外囊泡将炎症巨噬细胞重编程为依赖精氨酸酶 1 的促血管生成表型。
Am J Physiol Heart Circ Physiol. 2020 Jun 1;318(6):H1447-H1460. doi: 10.1152/ajpheart.00155.2020. Epub 2020 Apr 24.
6
Shear-Stress Sensitive Inwardly-Rectifying K Channels Regulate Developmental Retinal Angiogenesis by Vessel Regression.剪切应力敏感内向整流钾通道通过血管消退调节视网膜发育性血管生成。
Cell Physiol Biochem. 2019;52(6):1569-1583. doi: 10.33594/000000109.
7
Endogenous nitric oxide regulates blood vessel growth factors, capillaries in the cortex, and memory retention in Sprague-Dawley rats.内源性一氧化氮调节血管生长因子、皮质中的毛细血管以及Sprague-Dawley大鼠的记忆保持。
Am J Transl Res. 2016 Dec 15;8(12):5271-5285. eCollection 2016.
8
Effect of Blocking of Neuropeptide Y Y2 Receptor on Tumor Angiogenesis and Progression in Normal and Diet-Induced Obese C57BL/6 Mice.阻断神经肽Y Y2受体对正常及饮食诱导肥胖的C57BL/6小鼠肿瘤血管生成和进展的影响
Glob J Health Sci. 2015 Mar 26;7(7 Spec No):69-78. doi: 10.5539/gjhs.v7n7p69.
9
CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism.CXC-趋化因子受体 4 拮抗剂 AMD3100 通过内皮型一氧化氮合酶依赖的机制促进缺血/再灌注损伤后的心脏功能恢复。
Circulation. 2013 Jan 1;127(1):63-73. doi: 10.1161/CIRCULATIONAHA.112.099242. Epub 2012 Nov 30.
10
Signaling regulation of fetoplacental angiogenesis.胎儿胎盘血管生成的信号调控。
J Endocrinol. 2012 Mar;212(3):243-55. doi: 10.1530/JOE-11-0296. Epub 2011 Nov 21.
本文引用的文献
1
Endothelial cell proliferation as a novel approach to targeting tumour therapy.内皮细胞增殖作为一种靶向肿瘤治疗的新方法。
Br J Cancer. 1982 Jan;45(1):136-9. doi: 10.1038/bjc.1982.16.
2
Neovascular responses induced by cultured aortic endothelial cells.培养的主动脉内皮细胞诱导的新生血管反应。
J Cell Physiol. 1983 Mar;114(3):302-10. doi: 10.1002/jcp.1041140308.
3
4
A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation.一种从L-精氨酸生成一氧化氮的特异性抑制剂可减弱内皮依赖性舒张。
Br J Pharmacol. 1989 Feb;96(2):418-24. doi: 10.1111/j.1476-5381.1989.tb11833.x.
5
Tumor angiogenesis.肿瘤血管生成
Adv Cancer Res. 1985;43:175-203. doi: 10.1016/s0065-230x(08)60946-x.
6
Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators.一氧化氮生成性血管舒张剂对大鼠系膜细胞有丝分裂的抑制作用。
Am J Physiol. 1989 Jul;257(1 Pt 2):F60-6. doi: 10.1152/ajprenal.1989.257.1.F60.
7
Rate of basement membrane biosynthesis as an index to angiogenesis.基底膜生物合成速率作为血管生成的指标。
Tissue Cell. 1988;20(4):531-9. doi: 10.1016/0040-8166(88)90055-9.
8
Nitric oxide: physiology, pathophysiology, and pharmacology.一氧化氮：生理学、病理生理学与药理学
Pharmacol Rev. 1991 Jun;43(2):109-42.
9
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells.糖皮质激素可抑制腺癌细胞中一氧化氮合酶的诱导及相关细胞损伤。
Biochim Biophys Acta. 1991 Oct 21;1097(3):227-31. doi: 10.1016/0925-4439(91)90040-g.
Zotero 插件