罕见的正常B淋巴细胞表现出B细胞慢性淋巴细胞白血病的特征。
Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.
作者信息
Caligaris-Cappio F, Gobbi M, Bofill M, Janossy G
出版信息
J Exp Med. 1982 Feb 1;155(2):623-8. doi: 10.1084/jem.155.2.623.
Abstract
An infrequent (2-3%) B lymphocyte subpopulation was found in the normal human tonsil and lymph nodes that shows the phenotypic characteristics of B-chronic lymphocytic leukemia (B-CLL) (rosette formation with mouse erythrocytes, weak expression of membrane Ig, staining for HLA-DR, and OKT1 or Leu-1 detecting a T cell-associated p65 antigen). Preliminary evidence suggests that at least a subpopulation of these cells is found, in small proportions, within the germinal centers. These cells were not observed in the human bone marrow. B-CLL may involve this peripheral B lymphocyte subset.
摘要
在正常人类扁桃体和淋巴结中发现了一种罕见（2%-3%）的B淋巴细胞亚群，其表现出B细胞慢性淋巴细胞白血病（B-CLL）的表型特征（与小鼠红细胞形成玫瑰花结、膜免疫球蛋白表达较弱、HLA-DR染色以及OKT1或Leu-1检测到一种T细胞相关的p65抗原）。初步证据表明，这些细胞中至少有一个亚群少量存在于生发中心内。在人类骨髓中未观察到这些细胞。B-CLL可能累及这个外周B淋巴细胞亚群。
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