Subha K, Varalakshmi P
Department of Medical Biochemistry, Dr. A. L. Mudaliar Post Graduate Institute of Basic Medical Sciences, Taramani, India.
Biochem Mol Biol Int. 1993 Feb;29(2):271-80.
The effect of sodium pentosan polysulphate (SPP) was investigated in calcium oxalate stone forming rats with respect to the urinary excretion of certain risk factors and enzymes. Calcium oxalate stones were induced by feeding 3% w/w sodium glycollate to the rats. Urinary calcium, oxalate, phosphorus and uric acid levels were increased in stone formers. In contrast magnesium excretion was low in this group. SPP treatment lowered oxalate and calcium levels in both controls and experimental animals. Magnesium levels were increased moderately. Increased excretion of urinary enzymes--LDH, alkaline phosphatase, gamma-GT and beta glucuronidase--in calculogenic rats indicates membranuria and damage to proximal tubules during stone formation. Decreased pyrophosphatase activity was observed in glycollate fed rats. SPP treatment decreased the excretion of the above enzymes in the treated groups. Stone formers exhibited decreased LAP and fibrinolytic (urokinase) activities. SPP being associated with fibrinolytic properties, increased the activities of the above two enzymes to that of control levels in calculogenic rats.
研究了戊聚糖多硫酸钠（SPP）对草酸钙结石形成大鼠某些危险因素和酶的尿排泄的影响。通过给大鼠喂食3%（w/w）乙醇酸钠诱导草酸钙结石形成。结石形成大鼠的尿钙、草酸、磷和尿酸水平升高。相比之下，该组镁排泄量较低。SPP处理降低了对照组和实验动物的草酸和钙水平。镁水平适度升高。致石大鼠尿酶（乳酸脱氢酶、碱性磷酸酶、γ-谷氨酰转移酶和β-葡萄糖醛酸酶）排泄增加表明结石形成过程中存在膜尿症和近端肾小管损伤。在喂食乙醇酸钠的大鼠中观察到焦磷酸酶活性降低。SPP处理降低了治疗组上述酶的排泄。结石形成大鼠的亮氨酸氨基肽酶（LAP）和纤维蛋白溶解（尿激酶）活性降低。具有纤维蛋白溶解特性的SPP将上述两种酶的活性提高到致石大鼠的对照水平。
