Senthil D, Malini M M, Varalakshmi P
Department of Biochemistry, University of Madras, India.
Ren Fail. 1998 Jul;20(4):573-80. doi: 10.3109/08860229809045149.
Sodium pentosan polysulphate (SPP) has been shown to inhibit calcium oxalate crystallization in vitro. Here, the effect of SPP was studied on in vivo crystallization. Ammonium oxalate was used as the inducer of calcium oxalate crystallization in rats and the effect of SPP on in vivo crystallization factor is reported. The increased excretions of stone forming constituents associated with urinary marker enzymes are the salient features observed in experimental rats. Sodium pentosan polysulphate administration brought about a significant reduction in urinary stone forming constituents. It also decreased the extent of renal tubular damage as evidenced from the reduced level of marker enzymes in urine. These observations highlight the inhibitory capacity of SPP against in vivo calcium oxalate crystallization.
已证明戊聚糖多硫酸酯钠（SPP）在体外可抑制草酸钙结晶。在此，研究了SPP对体内结晶的影响。使用草酸铵作为大鼠草酸钙结晶的诱导剂，并报告了SPP对体内结晶因子的影响。与尿标记酶相关的结石形成成分排泄增加是在实验大鼠中观察到的显著特征。给予戊聚糖多硫酸酯钠可使尿结石形成成分显著减少。从尿中标记酶水平降低可证明，它还降低了肾小管损伤程度。这些观察结果突出了SPP对体内草酸钙结晶的抑制能力。
