Boevé E R, Cao L C, Verkoelen C F, Romijn J C, de Bruijn W C, Schröder F H
Department of Urology, Academic Hospital Dijkzigt, The Netherlands.
World J Urol. 1994;12(1):43-8. doi: 10.1007/BF00182050.
Naturally occurring glycosaminoglycans (GAGs) and other, semisynthetic, sulphated polysaccharides are thought to play an important role in urolithiasis. Processes involved in urinary stone formation are crystallization and crystal retention. Oxalate transport and renal tubular cell injury are determining factors in these processes. In this article experimental results concerning the possible mechanisms of action of GAGs and other sulphated polysaccharides are reviewed. GAGs are inhibitors of crystal growth and agglomeration and possibly also of nucleation. They can prevent crystal adherence, correct an abnormal oxalate flux and prevent renal tubular cell damage.
天然存在的糖胺聚糖（GAGs）以及其他半合成的硫酸化多糖被认为在尿石症中起重要作用。尿路结石形成过程涉及结晶和晶体滞留。草酸转运和肾小管细胞损伤是这些过程中的决定因素。本文综述了关于GAGs和其他硫酸化多糖可能作用机制的实验结果。GAGs是晶体生长和聚集的抑制剂，也可能是成核的抑制剂。它们可以防止晶体黏附，纠正异常的草酸通量并防止肾小管细胞损伤。
