Sentinelli S
Department of Histopathology, Misericordia Hospital, Grosseto, Italy.
Histopathology. 1993 Mar;22(3):271-4. doi: 10.1111/j.1365-2559.1993.tb00118.x.
A histochemical study of 27 well-differentiated prostatic carcinoma cases associated with prostatic intra-epithelial neoplasia (PIN) was carried out. In the histological areas examined a decreasing production of neutral mucin was found as follows: normal prostatic tissue (70%), prostatic carcinoma (55%), PIN 1 (50%), PIN 2 (30%) and PIN 3 (15%). A progressively increasing content of acidic mucin (AB 2.5) was observed in the areas of PIN 3 (25%), PIN 2 (35%) and prostatic carcinoma (70%), while it was absent in the areas of PIN 1 and normal prostatic tissue. Acidic mucin sulphated type (AB 1) was secreted only in PIN 3 (5%) and prostatic carcinoma (10%) areas. These data were correlated with the proliferative activity of PIN. It is postulated that the lower neutral mucin production by PIN 3 can be linked to the higher proliferative activity of this lesion. Moreover, the acidic mucin secretion by PIN and prostatic carcinoma is considered to be a further feature of these lesions.
对27例与前列腺上皮内瘤变（PIN）相关的高分化前列腺癌病例进行了组织化学研究。在所检查的组织学区域中，发现中性粘蛋白的产生减少情况如下：正常前列腺组织（70%）、前列腺癌（55%）、PIN 1（50%）、PIN 2（30%）和PIN 3（15%）。在PIN 3（25%）、PIN 2（35%）和前列腺癌（70%）区域观察到酸性粘蛋白（AB 2.5）含量逐渐增加，而在PIN 1和正常前列腺组织区域则不存在。硫酸化型酸性粘蛋白（AB 1）仅在PIN 3（5%）和前列腺癌（10%）区域分泌。这些数据与PIN的增殖活性相关。据推测，PIN 3中性粘蛋白产生较低可能与该病变较高的增殖活性有关。此外，PIN和前列腺癌分泌酸性粘蛋白被认为是这些病变的另一个特征。
