Freund K B, Yannuzzi L A, Sorenson J A
LuEsther T. Mertz Retinal Research Laboratory, Manhattan Eye, Ear and Throat Hospital, New York, New York.
Am J Ophthalmol. 1993 Jun 15;115(6):786-91. doi: 10.1016/s0002-9394(14)73649-9.
The neovascular variant of age-related macular degeneration is amenable to laser photocoagulation treatment within well-defined guidelines established by clinical trials. However, only a limited number of patients meet eligibility criteria for this form of treatment, principally because of the ill-defined, or occult nature, of the choroidal neovascularization commonly seen. Previous studies have estimated that one half of patients with neovascular age-related macular degeneration have occult neovascularization at initial manifestation of the disease. We examined the initial findings of 67 patients with newly diagnosed unilateral neovascular age-related macular degeneration. Eighty-seven percent of these patients (58 of 67) had disease that did not meet Macular Photocoagulation Study Group guidelines for laser photocoagulation treatment. As so few patients are eligible for laser photocoagulation, further research into new techniques of diagnosis and treatment for this disorder is warranted.
年龄相关性黄斑变性的新生血管变异型，在临床试验确立的明确指导原则范围内，适合进行激光光凝治疗。然而，只有少数患者符合这种治疗形式的入选标准，主要原因是常见的脉络膜新生血管界定不清或隐匿性。既往研究估计，新生血管性年龄相关性黄斑变性患者中有一半在疾病初发时存在隐匿性新生血管。我们检查了67例新诊断的单侧新生血管性年龄相关性黄斑变性患者的初始检查结果。这些患者中有87%（67例中的58例）的病情不符合黄斑光凝研究组激光光凝治疗的指导原则。由于 eligible for laser photocoagulation 的患者如此之少，因此有必要对这种疾病的新诊断和治疗技术进行进一步研究。
