通过基序预测HLA B8限制性流感表位
Prediction of an HLA B8-restricted influenza epitope by motif.
作者信息
Suhrbier A, Schmidt C, Fernan A
机构信息
Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia.
出版信息
Immunology. 1993 May;79(1):171-3.
Abstract
Alignment of previously identified HLA B8-restricted cytotoxic T-cell (CTL) epitopes revealed a common motif: x, x, K/R, x, R/K, x, W/Y, x, I/L. Of five motif-conforming peptides tested, ELRSRYWAI was found to represent a new epitope from influenza nucleoprotein (NP). High concentrations of some peptides gave cross-reactive stimulation illustrating the requirement to confirm epitope assignment with recombinant vaccinias and highlighting a potential problem of peptide-based CTL vaccines.
摘要
对先前鉴定出的HLA B8限制性细胞毒性T细胞（CTL）表位进行比对后发现了一个共同基序：x、x、K/R、x、R/K、x、W/Y、x、I/L。在测试的五个符合基序的肽段中，ELRSRYWAI被发现代表来自流感核蛋白（NP）的一个新表位。某些肽段的高浓度会产生交叉反应性刺激，这表明需要用重组痘苗来确认表位归属，并突出了基于肽的CTL疫苗的一个潜在问题。
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