酵母杀伤病毒热可治愈性的遗传学

Genetics of heat-curability of killer virus of yeast.

作者信息

Weinstein L A, Capaldo-Kimball F, Leibowitz M J

机构信息

Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854-5635.

出版信息

Yeast. 1993 Apr;9(4):411-8. doi: 10.1002/yea.320090411.

DOI:10.1002/yea.320090411

PMID:7685559

Abstract

The cytoplasmically inherited M double-stranded (ds) RNA genome segment of killer virus of Saccharomyces cerevisiae is heat-curable in some yeast strains but not in others. Temperature sensitivity is conferred on both M1 and M2 dsRNA satellite virus segments by the L-A-HN allele of the killer helper virus genome, but not by the L-A-H allele. Both diploidy and mating type heterozygosity of the host cell are also correlated with increased virus curability.

摘要

酿酒酵母杀伤病毒的细胞质遗传M双链（ds）RNA基因组片段在一些酵母菌株中可被热治愈，但在其他菌株中则不然。杀伤辅助病毒基因组的L-A-HN等位基因赋予M1和M2双链RNA卫星病毒片段温度敏感性，而L-A-H等位基因则不会。宿主细胞的二倍体状态和交配型杂合性也与病毒治愈率的提高相关。