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酵母杀伤病毒热可治愈性的遗传学

Genetics of heat-curability of killer virus of yeast.

作者信息

Weinstein L A, Capaldo-Kimball F, Leibowitz M J

机构信息

Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854-5635.

出版信息

Yeast. 1993 Apr;9(4):411-8. doi: 10.1002/yea.320090411.

DOI:10.1002/yea.320090411
PMID:7685559
Abstract

The cytoplasmically inherited M double-stranded (ds) RNA genome segment of killer virus of Saccharomyces cerevisiae is heat-curable in some yeast strains but not in others. Temperature sensitivity is conferred on both M1 and M2 dsRNA satellite virus segments by the L-A-HN allele of the killer helper virus genome, but not by the L-A-H allele. Both diploidy and mating type heterozygosity of the host cell are also correlated with increased virus curability.

摘要

酿酒酵母杀伤病毒的细胞质遗传M双链(ds)RNA基因组片段在一些酵母菌株中可被热治愈,但在其他菌株中则不然。杀伤辅助病毒基因组的L-A-HN等位基因赋予M1和M2双链RNA卫星病毒片段温度敏感性,而L-A-H等位基因则不会。宿主细胞的二倍体状态和交配型杂合性也与病毒治愈率的提高相关。

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The [KIL-d] cytoplasmic genetic element of yeast results in epigenetic regulation of viral M double-stranded RNA gene expression.
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