Ermis A, Hopf T, Hanselmann R, Remberger K, Welter C, Dooley S, Zang K D, Henn W
Institute of Human Genetics, Saarland University, Homburg/Saar, Germany.
Genes Chromosomes Cancer. 1993 Apr;6(4):232-4. doi: 10.1002/gcc.2870060407.
Cytogenetic analysis of primary cell cultures and/or passages 1-3 of synovial tissue from seven patients with rheumatoid arthritis was performed. As the only recurrent chromosome aberration, trisomy 7 was found in six of seven cultures. In four cultures, trisomy 7 occurred as a clonal change in up to 20% of the analyzed cells, with an increase of the proportion of cells with +7 with the duration of the in vitro culture. Apart from this recurrent change, a variety of partly clonal, partly nonclonal numerical and structural chromosome aberrations were observed in all cases. These findings support the view that clonal chromosome aberrations may play a role in the pathogenesis of invasive growth of the synovial tissue in rheumatoid arthritis although the localized synovial hyperproliferation is not a true neoplastic process.
对7例类风湿性关节炎患者的原代细胞培养物和/或滑膜组织传代1 - 3代进行了细胞遗传学分析。作为唯一反复出现的染色体畸变，在7个培养物中的6个中发现了7号染色体三体。在4个培养物中，7号染色体三体作为一种克隆性变化出现在高达20%的分析细胞中，并且随着体外培养时间的延长，+7细胞的比例增加。除了这种反复出现的变化外，在所有病例中还观察到各种部分克隆性、部分非克隆性的染色体数目和结构畸变。这些发现支持了这样一种观点，即克隆性染色体畸变可能在类风湿性关节炎滑膜组织侵袭性生长的发病机制中起作用，尽管局部滑膜过度增殖并非真正的肿瘤形成过程。
