Beresford S A, Chant A D, Jones H O, Piachaud D, Weddell J M
Lancet. 1978 Apr 29;1(8070):921-4. doi: 10.1016/s0140-6736(78)90694-3.
A randomised controlled trial was carried out to compare the clinical outcome 5 years after inpatient surgery and outpatient injection/compression sclerotherapy. 91.3% of those originally treated by injection/compression sclerotherapy and 93.9% of those originally treated surgically were seen at follow-up. 40% of patients treated initially by injection/compression sclerotherapy and 24.2% of those treated surgically were given further treatment. The probability of having no further treatment is significantly greater for those treated surgically. The improved outcome after surgery increased with age, being most striking in those aged over 45. The implications of the 5-year follow-up findings for the long-term cost of treatment are discussed.
开展了一项随机对照试验，以比较住院手术和门诊注射/压迫硬化疗法5年后的临床结果。最初接受注射/压迫硬化疗法治疗的患者中有91.3%以及最初接受手术治疗的患者中有93.9%在随访时接受了检查。最初接受注射/压迫硬化疗法治疗的患者中有40%以及接受手术治疗的患者中有24.2%接受了进一步治疗。接受手术治疗的患者不再接受进一步治疗的可能性显著更高。手术后改善的结果随年龄增加，在45岁以上的患者中最为显著。讨论了5年随访结果对长期治疗成本的影响。
