Ben-Aryeh H, Gordon N, Szargel R, Toubi E, Laufer D
Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel.
Oral Surg Oral Med Oral Pathol. 1993 Jun;75(6):696-9. doi: 10.1016/0030-4220(93)90425-4.
Whole saliva composition and flow rate were examined in 22 patients with systemic lupus erythematosus and compared with matched healthy controls. Significantly lowered salivary flow rate was observed in patients with systemic lupus erythematosus unrelated to the subjective complaint of xerostomia. Salivary sodium, calcium, and magnesium concentrations were significantly higher in the SLE patients with systemic lupus erythematosus, whereas potassium and total protein concentrations and amylase activity did not differ significantly from the controls. Salivary IgA and IgM levels were significantly higher in the patients than in controls. IgA, IgG, IgM, C3, C4, antinuclear antibody, and anti-DNA antibody levels were measured in serum of the patients with systemic lupus erythematosus and correlated with salivary immunoglobulins. The only significant correlation between saliva and serum was found between levels of salivary IgG and serum anti-DNA antibody. The altered salivary composition might indicate a subclinical involvement of salivary glands in the patients.
对22例系统性红斑狼疮患者的全唾液成分和流速进行了检测，并与配对的健康对照者进行比较。在与口干主观症状无关的系统性红斑狼疮患者中观察到唾液流速显著降低。系统性红斑狼疮患者的唾液钠、钙和镁浓度显著高于健康对照者，而钾、总蛋白浓度和淀粉酶活性与对照者无显著差异。患者的唾液IgA和IgM水平显著高于对照者。检测了系统性红斑狼疮患者血清中的IgA、IgG、IgM、C3、C4、抗核抗体和抗DNA抗体水平，并将其与唾液免疫球蛋白进行相关性分析。唾液与血清之间唯一显著的相关性发现于唾液IgG水平与血清抗DNA抗体水平之间。唾液成分的改变可能表明患者唾液腺存在亚临床受累情况。
