Ondokuz Mayis University, Faculty of Dentistry, Department of Paediatric Dentistry, 55139 Samsun, Turkey.
Arch Oral Biol. 2009 May;54(5):457-63. doi: 10.1016/j.archoralbio.2009.01.017. Epub 2009 Feb 26.
To evaluate the relationship between passive smoking as determined by salivary cotinine levels and salivary electrolytes, protein, secretory IgA, sialic acid and amylase in children.
Saliva was collected from 90 passive smoker (PS) subjects (the study group) and 90 healthy age-matched children (the control group). The study group was divided into three subgroups according the number of cigarettes smoked. Socio-economic status, dental and dietary habits were recorded by questionnaire. Stimulated salivary calcium (Ca), phosphate (P), sodium (Na), potassium (P), total protein, amylase activity, sialic acid level, secretory IgA concentration and cotinine level were analysed. All data were analysed using SPSS, version 13.0.
Socio-economic status, dental and dietary habits were similar between the two groups. The salivary electrolytes concentrations did not reveal significant difference between the two groups (p>0.05). The mean cotinine levels of PS children were 1.58+/-4.3 ng/mL. The salivary concentrations of protein were similar between the two groups (p>0.05). The salivary secretory IgA concentration was significantly lower in the PS group than controls. The sialic acid level and amylase activity in PS group were found significantly higher compared with the controls (p<0.05). No difference was observed for all these parameters with sex (p>0.05). When saliva samples were analysed for output, the sialic acid level and amylase activity increased significantly in PS subjects (p<0.05). Further, the output of secretory IgA concentration was found significantly lower compared with the controls (p<0.05).
In conclusion, we show that passive smoking was associated with a decrease in secretory IgA concentration, whereas with increase in amylase activity and sialic acid level of stimulated whole saliva in young children.
评估唾液可替宁水平所确定的被动吸烟与唾液电解质、蛋白质、分泌型免疫球蛋白 A、唾液酸和淀粉酶之间的关系。
收集 90 名被动吸烟儿童（研究组）和 90 名健康年龄匹配的儿童（对照组）的唾液。根据吸烟支数，研究组分为三组。通过问卷调查记录社会经济状况、口腔和饮食习惯。分析刺激唾液钙（Ca）、磷（P）、钠（Na）、钾（K）、总蛋白、淀粉酶活性、唾液酸水平、分泌型免疫球蛋白 A 浓度和可替宁水平。所有数据均使用 SPSS 13.0 进行分析。
两组的社会经济状况、口腔和饮食习惯相似。两组间唾液电解质浓度无显著差异（p>0.05）。PS 儿童的平均可替宁水平为 1.58+/-4.3 ng/mL。两组间唾液蛋白浓度相似（p>0.05）。PS 组的唾液分泌型免疫球蛋白 A 浓度明显低于对照组。PS 组的唾液酸水平和淀粉酶活性明显高于对照组（p<0.05）。所有这些参数与性别无关（p>0.05）。当分析唾液分泌量时，PS 组的唾液酸水平和淀粉酶活性显著增加（p<0.05）。此外，与对照组相比，PS 组分泌型免疫球蛋白 A 浓度明显降低（p<0.05）。
综上所述，我们发现儿童被动吸烟与分泌型免疫球蛋白 A 浓度降低有关，而与唾液淀粉酶活性和唾液酸水平升高有关。
