Kitazawa M, Nakagawa M, Baba O, Sumiyoshi K, Saito Y, Nishimura T, Bamba T, Hosoda S
Department of Internal Medicine, Kohga Public Hospital.
Kokyu To Junkan. 1993 Apr;41(4):393-6.
The patient was a 72-year-old man, who was admitted to our hospital because of cough. Chest X-rays showed a mass shadow in the right lower lung field. Amylase activities in serum and urine were extremely high. Amylase isozyme pattern identified salivary type amylase. Cytological examination of the sputum suggested adenocarcinoma. Amylase activities in serum and urine gradually decreased with the administration of chemotherapy. Afterwards, pleural effusion increased, and the amylase activity in pleural fluid was also extremely high. Pleural fluid also showed adenocarcinoma. Enzyme-labeled antibody method (PAP) on this specimen from pleural fluid proved that tumor cells were producing amylase ectopically.
患者为一名72岁男性，因咳嗽入院。胸部X光片显示右下肺野有一肿块阴影。血清和尿液中的淀粉酶活性极高。淀粉酶同工酶谱鉴定为唾液型淀粉酶。痰液细胞学检查提示为腺癌。随着化疗的进行，血清和尿液中的淀粉酶活性逐渐降低。此后，胸腔积液增多，胸腔积液中的淀粉酶活性也极高。胸腔积液也显示为腺癌。对该胸腔积液标本进行酶标抗体法（PAP）检测证明肿瘤细胞在异位产生淀粉酶。
