Adamson A S, Francis J L, Witherow R O, Snell M E
Department of Urology, St Mary's Hospital, London.
Br J Urol. 1993 May;71(5):587-92. doi: 10.1111/j.1464-410x.1993.tb16030.x.
Recent investigations have suggested that levels of urinary tissue factor (UTF) may be elevated in some forms of cancer. We have determined UTF levels in healthy controls, patients presenting for surgery with benign prostatic hypertrophy (BPH) and untreated prostate cancer. Patients undergoing check cystoscopy, who were free of recurrent bladder cancer, and a cohort of men with bone scan positive prostate cancer recently treated by androgen ablation were also studied. UTF levels were higher in patients with prostate cancer when compared with controls, those undergoing check cystoscopy and patients with BPH. In patients with prostate cancer, bone scan positive patients had higher levels than bone scan negative subjects. The androgen ablated group had UTF levels similar to those of the control groups and significantly lower than the bone scan positive group. A weak correlation was found between UTF and serum prostate specific antigen (PSA) levels when patients with BPH and untreated cancer were analysed, but no correlation was demonstrable between PSA and UTF when cancer patients alone were evaluated. It was concluded that UTF levels are elevated in untreated prostate cancer and reflect bone scan status. In patients with bone scan positive disease UTF also reflects disease activity and may therefore be a useful disease marker in prostate cancer.
近期研究表明，某些癌症患者的尿组织因子（UTF）水平可能会升高。我们测定了健康对照者、因良性前列腺增生（BPH）接受手术的患者以及未经治疗的前列腺癌患者的UTF水平。还研究了接受检查性膀胱镜检查且无复发性膀胱癌的患者，以及一组近期接受雄激素消融治疗且骨扫描显示前列腺癌阳性的男性。与对照组、接受检查性膀胱镜检查的患者以及BPH患者相比，前列腺癌患者的UTF水平更高。在前列腺癌患者中，骨扫描阳性患者的UTF水平高于骨扫描阴性患者。雄激素消融组的UTF水平与对照组相似，且显著低于骨扫描阳性组。分析BPH患者和未经治疗的癌症患者时，发现UTF与血清前列腺特异性抗原（PSA）水平之间存在弱相关性，但仅评估癌症患者时，未发现PSA与UTF之间存在相关性。得出的结论是，未经治疗的前列腺癌患者的UTF水平升高，且反映骨扫描状态。在骨扫描阳性疾病患者中，UTF也反映疾病活动情况，因此可能是前列腺癌的一种有用的疾病标志物。
