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钒盐与糖尿病的未来治疗

Vanadium salts and the future treatment of diabetes.

作者信息

Shechter Y, Shisheva A

机构信息

Department of Hormone Research, Weizmann Institute of Science, Israel.

出版信息

Endeavour. 1993 Mar;17(1):27-31. doi: 10.1016/0160-9327(93)90008-q.

DOI:10.1016/0160-9327(93)90008-q
PMID:7686098
Abstract

Until the discovery of insulin by Banting and Best in 1922, diabetes had a high mortality rate. Since then regular administration of the drug has brought it under control. Nevertheless it is not an ideal drug, in that it has to be injected and because of the incidence of insulin resistance. There is, therefore, a need for alternative forms of treatment and in recent years interest has centred on the possibilities of vanadium salts.

摘要

在1922年班廷和贝斯特发现胰岛素之前,糖尿病的死亡率很高。从那时起,定期注射这种药物已使其得到控制。然而,它并不是一种理想的药物,因为它必须注射,而且存在胰岛素抵抗的情况。因此,需要其他治疗方式,近年来人们的兴趣集中在钒盐的可能性上。

相似文献

1
Vanadium salts and the future treatment of diabetes.钒盐与糖尿病的未来治疗
Endeavour. 1993 Mar;17(1):27-31. doi: 10.1016/0160-9327(93)90008-q.
2
[Role of vanadium in the treatment of diabetes mellitus. Experimental data and clinical applications].
Presse Med. 1992 Jun 27;21(24):1100-1.
3
The insulin-like properties of vanadium: a curiosity or a perspective for the treatment of diabetes?钒的胰岛素样特性:是一种新奇现象还是治疗糖尿病的前景?
Diabete Metab. 1991 Sep-Oct;17(5):435-40.
4
Vanadium compounds as insulin mimics.钒化合物作为胰岛素模拟物。
Met Ions Biol Syst. 1995;31:575-94.
5
Oral vanadate and Tiron in treatment of diabetes mellitus in rats: improvement of glucose homeostasis and negative side-effects.口服钒酸盐和钛铁试剂对大鼠糖尿病的治疗作用:改善葡萄糖稳态及负面副作用
Vet Hum Toxicol. 1993 Dec;35(6):495-500.
6
Vanadium and diabetes. What about vanadium toxicity?钒与糖尿病。那钒的毒性呢?
Mol Cell Biochem. 2000 Jan;203(1-2):185-7. doi: 10.1023/a:1007067011338.
7
Comparison of the effects of various vanadium salts on glucose homeostasis in streptozotocin-diabetic rats.不同钒盐对链脲佐菌素诱导的糖尿病大鼠血糖稳态影响的比较
Eur J Pharmacol. 1994 Aug 1;260(2-3):169-75. doi: 10.1016/0014-2999(94)90334-4.
8
A new candidate for insulinomimetic vanadium complex: synergism of oxovanadium(IV)porphyrin and sodium ascorbate.
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1093-6. doi: 10.1016/j.bmcl.2003.12.081.
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The effects of vanadium treatment on bone in diabetic and non-diabetic rats.钒处理对糖尿病和非糖尿病大鼠骨骼的影响。
Bone. 2006 Mar;38(3):368-77. doi: 10.1016/j.bone.2005.08.015. Epub 2005 Oct 26.
10
Effect of chronic treatment with Bis(maltolato)oxovanadium (IV) in rat model of non-insulin-dependent-diabetes.双(麦芽醇)氧钒(IV)长期治疗对非胰岛素依赖型糖尿病大鼠模型的影响。
Indian J Exp Biol. 2001 Sep;39(9):864-70.

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Decavanadate possesses alpha-adrenergic agonist activity and a structural motif common with trans-beta form of noradrenaline.
十钒酸盐具有α-肾上腺素能激动剂活性,且具有与去甲肾上腺素反式-β形式相同的结构基序。
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The relationship between insulin and vanadium metabolism in insulin target tissues.胰岛素靶组织中胰岛素与钒代谢之间的关系。
Mol Cell Biochem. 1995;153(1-2):95-102. doi: 10.1007/BF01075923.
5
Unique and selective mitogenic effects of vanadate on SV40-transformed cells.钒酸盐对SV40转化细胞独特且具有选择性的促有丝分裂作用。
Mol Cell Biochem. 1995;153(1-2):59-67. doi: 10.1007/BF01075919.
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Toxicology of vanadium compounds in diabetic rats: the action of chelating agents on vanadium accumulation.钒化合物对糖尿病大鼠的毒理学:螯合剂对钒蓄积的作用
Mol Cell Biochem. 1995;153(1-2):233-40. doi: 10.1007/BF01075942.