Rosenblatt J D
Department of Medicine, University of California, School of Medicine, Los Angeles 90024-1678.
West J Med. 1993 Apr;158(4):379-84.
Human T-lymphotropic virus types I (HTLV-I) and II (HTLV-II) are members of a family of four known retroviruses that are oncogenic as opposed to cytopathic. This family includes HTLV-I and -II, bovine leukemia virus, and simian T-cell leukemia virus. The two types of HTLV are closely related, and for more than a decade we have been aware of the presence of these viruses in humans. In the first part of this article I summarize recent epidemiologic and clinical findings related to the presence of HTLV-I and -II in the Americas. In the second part, I discuss how these viruses may regulate themselves and how in turn they might cause leukemia and neurologic disease in humans.
人类嗜T淋巴细胞病毒I型（HTLV-I）和II型（HTLV-II）是四种已知逆转录病毒家族的成员，这些病毒具有致癌性而非细胞致病性。该家族包括HTLV-I和-II、牛白血病病毒以及猿猴T细胞白血病病毒。这两种HTLV密切相关，并且十多年来我们一直知晓这些病毒在人类中的存在。在本文的第一部分，我总结了与美洲地区HTLV-I和-II存在情况相关的近期流行病学和临床研究结果。在第二部分，我将讨论这些病毒如何进行自我调控，以及它们又如何反过来导致人类白血病和神经疾病。
