Sloan E P, Fenton G W
Department of Psychiatry, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
Electroencephalogr Clin Neurophysiol. 1993 Jun;86(6):361-7. doi: 10.1016/0013-4694(93)90131-e.
Elderly patients with senile dementia of the Alzheimer type (SDAT), multi-infarct dementia (MID) and functional psychiatric illness, along with elderly control subjects, were studied longitudinally at 6 monthly intervals over a 2 year period, with cognitive testing and EEG power spectral analyses being carried out on each occasion. There was no significant change in the EEG power over time although a significant regression effect was noted for cognitive performance in the SDAT group. A number of between-group differences were apparent. The SDAT patients had more delta and theta power and less alpha power than those with MID and the latter group had a higher percentage of delta and theta power than the functional patients. The functional patients and normal subjects were differentiated from each other by a number of EEG power variables. The implications of these findings with respect to differential diagnosis in geriatric psychiatry are discussed.
对患有阿尔茨海默型老年痴呆症（SDAT）、多发性梗死性痴呆（MID）和功能性精神疾病的老年患者，以及老年对照受试者，在两年时间内每隔6个月进行一次纵向研究，每次都进行认知测试和脑电图功率谱分析。尽管注意到SDAT组的认知表现有显著的回归效应，但脑电图功率随时间没有显著变化。组间存在一些明显差异。与MID患者相比，SDAT患者的δ波和θ波功率更高，α波功率更低，而后者的δ波和θ波功率百分比高于功能性患者。功能性患者和正常受试者通过多个脑电图功率变量相互区分。讨论了这些发现对老年精神病学鉴别诊断的意义。
