Pace A, Pietrangeli A, Bove L, Rosselli M, Lopez M, Jandolo B
Servizio di Neurologia, Istituto Regina Elena per lo Studio e la Cura di Tumori, Roma.
Ital J Neurol Sci. 1994 Oct;15(7):341-6. doi: 10.1007/BF02339930.
Antitumoral interleukin-2 (IL-2) therapy is frequently associated with a neurotoxicity that manifests itself in neuropsychiatric disturbances and, more rarely, with neurological focal signs. With the aim of documenting the involvement of cognitive functions after IL-2 treatment, we studied 20 patients using evoked cognitive potentials (P300) and computer analysis of the EEG signal. A comparison of the tests performed before and after the subcutaneous infusion of IL-2 showed a significant lengthening in mean P300 latencies and a percentage increase in the EEG frequencies contained with the delta and theta bands, especially in the frontal regions.
抗肿瘤白细胞介素-2（IL-2）治疗常伴有神经毒性，表现为神经精神障碍，较少出现神经局灶体征。为记录IL-2治疗后认知功能的受累情况，我们使用诱发认知电位（P300）和脑电图信号的计算机分析对20例患者进行了研究。皮下注射IL-2前后所做测试的比较显示，P300平均潜伏期显著延长，脑电图频率中δ和θ波段的百分比增加，尤其是在额叶区域。
