肝细胞癌患者的血清抗丙型肝炎病毒及丙型肝炎病毒RNA

[Serum anti-hepatitis C virus and hepatitis C virus RNA in patients with hepatocellular carcinoma].

作者信息

Jiang M D

机构信息

Department of Gastroenterology, General Hospital of Chengdu Command.

出版信息

Zhonghua Yi Xue Za Zhi. 1993 Mar;73(3):131-4, 189.

PMID:7686810

Abstract

Serum anti-HCV and HCV RNA (RT-PCR), possible association to the markers of hepatitis B virus (HBV-M) including HBsAg were evaluated in 48 patients with hepatocellular carcinoma (HCC). The results indicated that 13 were anti-HCV positive in HCC group and 5 in other cancers (control group, P < 0.05). Serum HCV RNA was detected in 11 patients with HCC (23%). The positive rate of HCV RNA and/or anti-HCV (HCV-M) was 38% in all HCC cases, 80% (12/15) in HBV-M (-) HCC, 58% (14/24) in HBsAg(-), 18% (6/33) in HBV-M(+), and 15% (4/24) in HBsAg(+). HBV-M and/or HCV-M was found positive in 45 patients with HCC (93.8%). Our study shows that both HBV and HCV infections are related to the development of HCC. HCV-M was found positive mostly in HBV-M negative HCC patients and serum HCV RNA replication existed in some of HCC cases.

摘要

对48例肝细胞癌（HCC）患者检测血清抗丙型肝炎病毒（HCV）和HCV核糖核酸（RNA）（逆转录-聚合酶链反应），并评估其与包括乙肝表面抗原（HBsAg）在内的乙肝病毒（HBV）标志物的可能关联。结果显示，HCC组中13例抗HCV阳性，其他癌症组（对照组）中5例阳性（P<0.05）。11例HCC患者检测到血清HCV RNA（23%）。所有HCC病例中HCV RNA和/或抗HCV（HCV标志物）阳性率为38%，HBV标志物（-）的HCC中为80%（12/15），HBsAg（-）中为58%（14/24），HBV标志物（+）中为18%（6/33），HBsAg（+）中为15%（4/24）。45例HCC患者中发现HBV标志物和/或HCV标志物阳性（93.8%）。我们的研究表明，HBV和HCV感染均与HCC的发生有关。HCV标志物大多在HBV标志物阴性的HCC患者中呈阳性，部分HCC病例存在血清HCV RNA复制。