Weier H U, George C X, Greulich K M, Samuel C E
Center for Molecular Cytogenetics, University of California, Lawrence Berkeley National Laboratory 94720, USA.
Genomics. 1995 Nov 20;30(2):372-5. doi: 10.1006/geno.1995.0034.
The interferon-inducible double-stranded RNA-specific adenosine deaminase is an RNA-modifying enzyme implicated in the generation of biased hypermutations viral RNAs and the site-selective editing of mammalian mRNAs of neural origin. The gene for the dsRNA-specific adenosine deaminase has been mapped by fluorescence in situ hybridization (FISH) of genomic clones to a single locus on human chromosome 1 bands q21.1-21.2. Simultaneous multicolor FISH including lambda clones and yeast artificial chromosomes showed a localization of the gene in band 1q21 centromeric of D1S1705.
干扰素诱导的双链RNA特异性腺苷脱氨酶是一种RNA修饰酶，与偏向性高突变病毒RNA的产生以及神经源性哺乳动物mRNA的位点选择性编辑有关。双链RNA特异性腺苷脱氨酶的基因已通过基因组克隆的荧光原位杂交（FISH）定位到人类染色体1的q21.1-21.2带的一个单一位点。包括λ克隆和酵母人工染色体的同步多色FISH显示该基因定位于D1S1705着丝粒的1q21带。
