Espinosa-Aguirre J J, Vilchis C, Ostrosky-Wegman P, Benitez L, Lares I, Rubio J
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, D.F.
Mutat Res. 1993 Aug;300(3-4):151-4. doi: 10.1016/0165-1218(93)90046-g.
The ability of cyclohexanol to inhibit the mutagenicity of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and of N-nitrosodiethylamine (NDEA) was tested on Salmonella typhimurium strain TA100. Cyclohexanol produced a dose-dependent decrease in the number of revertants induced by a single dose of NNK (24 mumoles) or NDEA (59 mumoles). Nevertheless, this inhibitory effect was not observed with other premutagenic agents such as benzo[a]pyrene and 2-aminoanthracene nor with direct mutagens such as ethyl methanesulfonate and methyl methanesulfonate. These results suggest that cyclohexanol interferes with the 'bioactivation' of the tested nitrosamines in a similar way that other alcohols such as ethanol or isopropanol interfere with N-nitro-sodimethylamine and NDEA metabolism.
在鼠伤寒沙门氏菌TA100菌株上测试了环己醇抑制烟草特有的亚硝胺4-(N-亚硝基甲基氨基)-1-(3-吡啶基)-1-丁酮（NNK）和N-亚硝基二乙胺（NDEA）致突变性的能力。环己醇使单剂量NNK（24微摩尔）或NDEA（59微摩尔）诱导的回复突变菌落数呈剂量依赖性减少。然而，在用其他前诱变剂如苯并[a]芘和2-氨基蒽以及直接诱变剂如甲磺酸乙酯和甲磺酸甲酯处理时，未观察到这种抑制作用。这些结果表明，环己醇以类似于乙醇或异丙醇等其他醇类干扰N-亚硝基二甲胺和NDEA代谢的方式，干扰了所测试亚硝胺的“生物活化”。
