慢性特发性荨麻疹：组胺释放因子对发病机制的可能作用。
Chronic idiopathic urticaria: possible contribution of histamine-releasing factor to pathogenesis.
作者信息
Claveau J, Lavoie A, Brunet C, Bédard P M, Hébert J
机构信息
Centre de Recherche en Inflammation et Immunologie-Rhumatologie, Le Centre Hospitalier de l'Université Laval, Sainte-Foy, Québec, Canada.
出版信息
J Allergy Clin Immunol. 1993 Jul;92(1 Pt 1):132-7. doi: 10.1016/0091-6749(93)90047-j.
BACKGROUND
Histamine-releasing factor was recently shown to be clinically relevant in allergic rhinitis and asthma. HRF could also be involved in the pathogenicity of chronic idiopathic urticaria (CU). The purpose of this study was to investigate the role of HRF in the pathophysiology of CU.
METHODS
Blisters were induced on lesional and nonlesional skin of 12 patients with CU and on normal skin of five control subjects. HRF activity and histamine content were measured in all samples recovered from each skin site.
RESULTS
Significantly more HRF was found in blister fluids from lesional skin of patients with CU as compared with nonlesional skin and skin of control subjects. In addition, histamine content in blister fluids from affected skin of patients with CU was significantly higher in comparison with both nonlesional skin of patients with CU and skin of control subjects. HRF activity was also higher in blister fluids from nonlesional skin of patients with CU than that of control subjects, in spite of equivalent histamine content.
CONCLUSION
These data suggest that the inflammatory reaction found in CU disease is associated with the cutaneous release of HRF.
背景
最近研究表明，组胺释放因子在变应性鼻炎和哮喘中具有临床相关性。组胺释放因子也可能参与慢性特发性荨麻疹（CU）的发病机制。本研究旨在探讨组胺释放因子在慢性特发性荨麻疹病理生理学中的作用。
方法
对12例慢性特发性荨麻疹患者的皮损和非皮损皮肤以及5例对照受试者的正常皮肤进行水疱诱导。测量从每个皮肤部位收集的所有样本中的组胺释放因子活性和组胺含量。
结果
与非皮损皮肤和对照受试者的皮肤相比，慢性特发性荨麻疹患者皮损皮肤水疱液中的组胺释放因子明显更多。此外，与慢性特发性荨麻疹患者的非皮损皮肤和对照受试者的皮肤相比，慢性特发性荨麻疹患者受累皮肤水疱液中的组胺含量明显更高。尽管组胺含量相当，但慢性特发性荨麻疹患者非皮损皮肤水疱液中的组胺释放因子活性也高于对照受试者。
结论
这些数据表明，慢性特发性荨麻疹疾病中发现的炎症反应与组胺释放因子的皮肤释放有关。
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