Takegawa S, Koizumi N, Takahashi H, Shibata K
Research Department of Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
Chem Pharm Bull (Tokyo). 1993 May;41(5):870-5. doi: 10.1248/cpb.41.870.
Oxygenated derivatives of 2-oxachlormadinone acetate (17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) at C11, C15, and C16 were prepared as potential antiandrogenic agents. Biological evaluation showed the 15 beta-hydroxyl compound to have a high potent antiandrogenic activity when tested in the castrated male rat.
制备了2-氧杂氯地孕酮醋酸酯（17-乙酰氧基-6-氯-2-氧杂孕甾-4,6-二烯-3,20-二酮）在C11、C15和C16位的氧化衍生物作为潜在的抗雄激素剂。生物学评价表明，在去势雄性大鼠中进行测试时，15β-羟基化合物具有高效的抗雄激素活性。
