通过转化生长因子-β1基因转染增强转移能力
Potentiation of metastatic capacity by transforming growth factor-beta 1 gene transfection.
作者信息
Ueki N, Ohkawa T, Yokoyama Y, Maeda J, Kawai Y, Ikeda T, Amuro Y, Hada T, Higashino K
机构信息
Third Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya.
出版信息
Jpn J Cancer Res. 1993 Jun;84(6):589-93. doi: 10.1111/j.1349-7006.1993.tb02017.x.
Abstract
This study was designed to assess whether the excessive secretion of transforming growth factor-beta 1 (TGF-beta 1) by Chinese hamster ovary (CHO) cells transfected with TGF-beta 1 gene may be linked to the development of a metastatic phenotype. We observed large numbers of metastatic colonies in the lungs of nude mice inoculated with the transfected CHO cells. The tumors derived from these transfected cells demonstrated marked angiogenesis. We postulate that the overproduction of TGF-beta 1 by these tumors may participate in the metastatic progression following establishment of angiogenesis at the primary tumor site.
摘要
本研究旨在评估转染了转化生长因子-β1（TGF-β1）基因的中国仓鼠卵巢（CHO）细胞中TGF-β1的过度分泌是否可能与转移表型的发展有关。我们在接种了转染CHO细胞的裸鼠肺部观察到大量转移瘤菌落。源自这些转染细胞的肿瘤表现出明显的血管生成。我们推测，这些肿瘤中TGF-β1的过量产生可能在原发性肿瘤部位建立血管生成后参与转移进程。
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