Emilie D, Galanaud P
Service de médecine interne et d'immunologie clinique, hôpital Antoine-Béclère, Clamart.
Rev Prat. 1993 Mar 1;43(5):565-8.
HIV infection is associated with abnormalities of cytokine production. A number of cytokines (IL-1, IL-6, TNF-alpha, interferons-alpha and -gamma) are produced at an increased level in vivo, whereas the production of IL-2 is decreased. This latter abnormality certainly plays an important role in the immunodeficiency of AIDS patients. Monokines (IL-1, IL-6, TNF-alpha) stimulate HIV replication in vitro, whereas the interferons decrease it. Cytokine effects on the in vivo spreading of HIV remain however to be determined. Cytokines may also be mediators of the clinical manifestations of AIDS. IL-1, IL-6 and TNF-alpha may induce tissue lesions of opportunistic infections and HIV encephalopathy. Cytokines, and mainly IL-6, may stimulate the growth of malignant cells in Kaposi sarcomas and in lymphomas. A better knowledge of the roles of cytokines in HIV infection may allow new therapeutic approaches using either recombinant cytokines or specific antagonists, with the aim of inhibiting both HIV spreading and the clinical manifestations of the infection.
HIV感染与细胞因子产生异常有关。多种细胞因子（白细胞介素-1、白细胞介素-6、肿瘤坏死因子-α、干扰素-α和-γ）在体内的产生水平升高，而白细胞介素-2的产生则减少。后一种异常在艾滋病患者的免疫缺陷中肯定起着重要作用。单核因子（白细胞介素-1、白细胞介素-6、肿瘤坏死因子-α）在体外刺激HIV复制，而干扰素则减少其复制。然而，细胞因子对HIV在体内传播的影响仍有待确定。细胞因子也可能是艾滋病临床表现的介质。白细胞介素-1、白细胞介素-6和肿瘤坏死因子-α可能诱导机会性感染的组织损伤和HIV脑病。细胞因子，主要是白细胞介素-6，可能刺激卡波西肉瘤和淋巴瘤中恶性细胞的生长。更好地了解细胞因子在HIV感染中的作用可能会带来新的治疗方法，即使用重组细胞因子或特异性拮抗剂，以抑制HIV传播和感染的临床表现。
