Emilie D, Fior R, Jarrousse B, Marfaing-Koka A, Merrien D, Devergne O, Crevon M C, Maillot M C, Galanaud P
INSERM U131, Clamart, France.
Int J Immunopharmacol. 1994 May-Jun;16(5-6):391-6. doi: 10.1016/0192-0561(94)90026-4.
Human immunodeficiency virus infection leads to a deregulated production of a number of cytokines. Some of them (IL-1, IL-6, TNF-alpha, interferon-gamma) are produced in increased amounts in vivo, whereas the production of IL-2 is decreased. This latter abnormality plays a pivotal role in the establishment of the immunodeficiency. Some cytokines (IL-1, IL-6, TNF-alpha) stimulate the in vitro replication of HIV, whereas others (mainly the interferons) inhibit it. The effect of cytokines in vivo in the spreading of HIV remains, however, largely unknown. Cytokines may also be involved in the development of many clinical manifestations associated with HIV infection. IL-1, IL-6 and TNF-alpha may play a role in tissue damages associated with opportunistic infections, in HIV-related encephalopathy and in cachexia. Cytokines, mainly IL-6, IL-10 and IL-13, may stimulate the growth of malignant cells during Kaposi sarcoma or lymphomas. Better knowledge of the role of cytokines during HIV infection should allow new therapeutic approaches based on the use of either recombinant cytokines or specific antagonists, with the aim of limiting both HIV spreading and the clinical manifestations of this infection.
人类免疫缺陷病毒感染导致多种细胞因子产生失调。其中一些细胞因子（白细胞介素-1、白细胞介素-6、肿瘤坏死因子-α、干扰素-γ）在体内产生量增加，而白细胞介素-2的产生量则减少。后一种异常在免疫缺陷的形成中起关键作用。一些细胞因子（白细胞介素-1、白细胞介素-6、肿瘤坏死因子-α）刺激人类免疫缺陷病毒在体外的复制，而其他细胞因子（主要是干扰素）则抑制其复制。然而，细胞因子在体内对人类免疫缺陷病毒传播的影响在很大程度上仍不清楚。细胞因子也可能参与与人类免疫缺陷病毒感染相关的许多临床表现的发展。白细胞介素-1、白细胞介素-6和肿瘤坏死因子-α可能在与机会性感染相关的组织损伤、人类免疫缺陷病毒相关脑病和恶病质中起作用。细胞因子，主要是白细胞介素-6、白细胞介素-10和白细胞介素-13，可能在卡波西肉瘤或淋巴瘤期间刺激恶性细胞的生长。更好地了解细胞因子在人类免疫缺陷病毒感染过程中的作用，应该能够基于使用重组细胞因子或特异性拮抗剂开发新的治疗方法，以限制人类免疫缺陷病毒的传播和这种感染的临床表现。
