Psychoyos A, Creatsas G, Hassan E, Georgoulias V, Gravanis A
Hôpital Bicêtre, (INSERM), Kremlin-Bicêtre, France.
Hum Reprod. 1993 Jun;8(6):866-9. doi: 10.1093/oxfordjournals.humrep.a138156.
Cholic acid (sodium cholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity. The same effects are observed for F-5 Gel, the active mixture of a new contraceptive sponge (Protectaid), which contains sodium cholate in association with low concentrations (0.5%) of nonoxynol-9 and benzalkonium chloride. Both cholic acid and the F-5 Gel exert a dose-dependent, in-vitro inhibitory effect (i) on the activity of HIV-1 associated reverse transcriptase in an acellular system and (ii) on the potential of HIV-1 efficiently to infect human lymphocytes. During 12 months use, the contraceptive efficacy of the 'Protectaid' sponge was 100% in 20 young women who had chosen this method for reasons of both contraception and anti-sexually transmitted disease. No side-effects were recorded throughout this period. Cervical cultures at 6-month intervals showed the presence of Mycoplasma hominis and Candida albicans in one or two cases. The combined spermicidal and anti-HIV properties of cholic acid reported in this paper and used in the 'Protectaid' sponge offer a new and modern protective method of contraception.
胆酸（胆酸钠）具有很强的杀精和抗病毒[抗人类免疫缺陷病毒（HIV）-1]活性。对于F-5凝胶也观察到了同样的效果，F-5凝胶是一种新型避孕海绵（Protectaid）的活性混合物，它含有胆酸钠以及低浓度（0.5%）的壬苯醇醚-9和苯扎氯铵。胆酸和F-5凝胶在体外均呈现剂量依赖性抑制作用：（i）在无细胞系统中对HIV-1相关逆转录酶的活性，（ii）对HIV-1有效感染人类淋巴细胞的能力。在12个月的使用期间，对于20名因避孕和预防性传播疾病而选择这种方法的年轻女性，“Protectaid”海绵的避孕效果为100%。在此期间未记录到任何副作用。每隔6个月进行的宫颈培养显示，有一或两例存在人型支原体和白色念珠菌。本文报道的并用于“Protectaid”海绵中的胆酸的联合杀精和抗HIV特性提供了一种新型的现代避孕保护方法。
