Jennings R, Clegg A
Department of Experimental and Clinical Microbiology, University of Sheffield Medical School, UK.
J Antimicrob Chemother. 1993 Jul;32(1):71-82. doi: 10.1093/jac/32.1.71.
Five spermicides including nonoxynol-9 were assessed under in-vitro conditions, for their inhibitory activity against two viruses capable of spread by sexual intercourse, herpes simplex virus type-2 (HSV-2) and the human immunodeficiency virus type-1. A further eight commercially-available spermicidal preparations containing varying concentrations of either nonoxynol-9 or nonoxynol-11 were also assessed for activity against HSV-2. All spermicides and spermicidal preparations tested showed inhibitory activity against both viruses over periods of time ranging from 30 sec to 5 min. This activity was dependent on the concentration of spermicide to which the viruses were exposed.
对包括壬苯醇醚-9在内的五种杀精剂进行了体外评估，以检测它们对两种可通过性交传播的病毒——2型单纯疱疹病毒（HSV-2）和1型人类免疫缺陷病毒的抑制活性。还对另外八种含有不同浓度壬苯醇醚-9或壬苯醇醚-11的市售杀精制剂进行了抗HSV-2活性评估。所有测试的杀精剂和杀精制剂在30秒至5分钟的时间段内均显示出对这两种病毒的抑制活性。这种活性取决于病毒所接触的杀精剂浓度。
