Lin H X, Gontier C, Saron M F, Perrin P
Rabies Unit, Institut Pasteur, Paris, France.
Arch Virol. 1993;131(3-4):307-19. doi: 10.1007/BF01378634.
The activity of an immunostimulatory complex (PICKCa) which is widely used against several human diseases in China was tested in experimental rabies prophylaxis. PICKCa protected mice against peripheral infection with both fixed and wild rabies strains. It also enhanced the protective activity of an experimental rabies vaccine injected either before or after rabies infection. PICKCa enhanced both non-specific immune responses and specific immunity including antibody production and cell mediated immunity as assessed by interleukin-2 production.
在中国广泛用于对抗多种人类疾病的免疫刺激复合物（PICKCa）的活性，在实验性狂犬病预防中进行了测试。PICKCa保护小鼠免受固定毒株和野生狂犬病毒株的外周感染。它还增强了在狂犬病感染之前或之后注射的实验性狂犬病疫苗的保护活性。如通过白细胞介素-2产生所评估的，PICKCa增强了非特异性免疫反应以及包括抗体产生和细胞介导免疫在内的特异性免疫。
