Fearon D T
University of Cambridge School of Clinical Medicine, UK.
Curr Opin Immunol. 1993 Jun;5(3):341-8. doi: 10.1016/0952-7915(93)90051-s.
A paradigm describing the response of T lymphocytes to antigen holds that signals from antigen receptors must be modulated by non-antigen-specific, accessory membrane proteins for an appropriate cellular response to occur, such as differentiation, activation and tolerance. Recent studies suggest that this paradigm applies also to B lymphocytes. Signaling through membrane IgM in these cells requires CD45, a phosphotyrosine phosphatase, and is amplified by a complex containing CD19, complement receptor 2 (CD21), and TAPA-1, which recruits the intracellular enzyme, phosphatidylinositol 3-kinase.
一种描述T淋巴细胞对抗原反应的模式认为，来自抗原受体的信号必须由非抗原特异性的辅助膜蛋白进行调节，才能发生适当的细胞反应，如分化、激活和耐受。最近的研究表明，这种模式也适用于B淋巴细胞。这些细胞中通过膜IgM的信号传导需要CD45（一种磷酸酪氨酸磷酸酶），并由一个包含CD19、补体受体2（CD21）和TAPA-1的复合物进行放大，该复合物可募集细胞内酶磷脂酰肌醇3激酶。
