Podkuĭko V N, Vorob'ev A A, Krasnianskiĭ V P, Patrikeev G T, Mikhaĭlov V V, Dorokhina T V, Makhlaĭ A A, Dykanov G A
Vestn Ross Akad Med Nauk. 1993(2):39-44.
Oral and dermal administrations of vaccinia virus into rabbits, guinea pigs, and monkeys demonstrated a milder (without homeostasis disturbance) course of the vaccinal process with oral immunization, intensive immunity forming in minimal sensitization of the body was compared with dermal one. The results of revaccination in adults with oral smallpox vaccine and primary immunization in Ethiopia showed that oral immunization with vaccinia virus was safe, effective and lowly reactogenic. The comparative study of the preparation in remote revaccination (5 or more years later) proved its advantage over dermal vaccine. It consists in ecological safety (vaccinia virus excretion into the environment during 1 and 11 days, respectively, by 10-fold concentration reduction), reactogenicity (5 and 33% of common reactions, respectively) in the same immunogenicity.
对兔、豚鼠和猴进行牛痘病毒口服和皮肤给药试验表明，口服免疫时疫苗接种过程较为温和（无体内平衡紊乱），与皮肤免疫相比，在机体最小程度致敏的情况下能形成较强的免疫力。在成年人中进行口服天花疫苗再接种以及在埃塞俄比亚进行初次免疫的结果表明，口服牛痘病毒免疫是安全、有效的，且反应原性较低。对该制剂在远距离再接种（5年或更长时间后）中的比较研究证明了其相对于皮肤疫苗的优势。这体现在生态安全性（牛痘病毒分别在1天和11天内排泄到环境中，浓度降低10倍）、反应原性（常见反应分别为5%和33%）以及相同的免疫原性上。
