Jha S, Nag D, Shukla R, Kar A M, Kumar A
Department of Neurology, King George's Medical College, Lucknow.
J Indian Med Assoc. 1993 Mar;91(3):53-4.
Thirty-eight patients of generalised tonic-clonic seizures of epileptics in the age group of 15-30 years were included in this study. Of these 20 were started sodium valproate afresh and 18 already taking it for more than one year prior to inclusion. Serum amylase and serum valproic acid levels were measured in all of them, initially and at every 3 months interval for 9 months. Though no clinical evidence was present, there was significant increase in serum amylase levels in both the groups which has no correlation with dose or serum valproic acid levels.
本研究纳入了38例年龄在15至30岁之间的癫痫全身性强直阵挛发作患者。其中20例重新开始服用丙戊酸钠，18例在纳入研究前已服用该药超过一年。对所有患者在初始时以及之后每3个月测量一次血清淀粉酶和血清丙戊酸水平，持续9个月。虽然没有临床证据，但两组患者的血清淀粉酶水平均显著升高，且与剂量或血清丙戊酸水平无关。
