Wu X, Ma J J
Department of Neurology, First Affiliated Hospital, Beijing Medical University, China.
Clin Electroencephalogr. 1993 Apr;24(2):93-9. doi: 10.1177/155005949302400211.
Twelve healthy adults and 12 epileptics had quantitative EEG tests while taking valproic acid. The results indicated that the total power of dominant frequency band and the frequency of dominant occipital rhythm were relatively stable in healthy awake adults. A single 400 mg oral dose of sodium valproate had similar influence on the total power of dominant frequency band in both healthy adults and epileptics. The total power of dominant frequency band tended to rise at 2 and 6 hours after medication in subjects with serum VPA concentrations reaching a peak after 2 hours. There was a tendency to rise at 4 and 8 hours in subjects with serum VPA concentrations which peaked after 4 hours. The curve of the total power with time had two peaks. A single oral dose of sodium valproate did not have a marked influence on the frequency of dominant rhythm in the occipital areas in healthy adults or in epileptics.
12名健康成年人和12名癫痫患者在服用丙戊酸期间进行了定量脑电图测试。结果表明，健康清醒成年人的优势频段总功率和枕部优势节律频率相对稳定。单次口服400mg丙戊酸钠对健康成年人和癫痫患者的优势频段总功率有相似影响。血清VPA浓度在2小时后达到峰值的受试者，用药后2小时和6小时优势频段总功率有上升趋势。血清VPA浓度在4小时后达到峰值的受试者，在4小时和8小时有上升趋势。总功率随时间的曲线有两个峰值。单次口服丙戊酸钠对健康成年人或癫痫患者枕部区域的优势节律频率没有显著影响。
