Mackay D R, Manders E K, Saggers G C, Schenden M J, Zaino R
Division of Plastic and Reconstructive Surgery, Pennsylvania State University, College of Medicine, Milton S. Hershey Medical Center, Hershey 17033.
Ann Plast Surg. 1993 Jul;31(1):42-6.
Histological changes in dermis and dermal-fat grafts have been hampered by the lack of a defined boundary to allow precise localization. We describe a model in which grafts of skin components were coated with india ink and implanted over the perichondrium of pigs' ears. Histological studies were then performed at 2-weekly intervals for 10 weeks. The survival of the grafts was also quantified. Skin adnexal structures found in dermal grafts survived with some changes. Grafts with an epithelial component produced an intense inflammatory infiltrate and formed inclusion cysts. Fat tended to disappear, a significant part of it being replaced by fibrous tissue. Dermis grafts implanted in the ears of growing pigs not only survived, but grew.
由于缺乏明确的边界以实现精确定位，真皮和真皮 - 脂肪移植的组织学变化研究受到了阻碍。我们描述了一种模型，即将皮肤成分移植体用印度墨水包被后植入猪耳软骨膜上。然后在10周内每隔2周进行组织学研究。还对移植体的存活情况进行了量化。真皮移植体中发现的皮肤附属器结构虽有一些变化但仍存活。带有上皮成分的移植体产生强烈的炎性浸润并形成包涵囊肿。脂肪往往会消失，其中很大一部分被纤维组织取代。植入生长猪耳部的真皮移植体不仅存活，而且还会生长。
