Kraal G, van Wilsem E, Brevé J
Department of Cell Biology, Vrije Universiteit, Amsterdam, The Netherlands.
In Vivo. 1993 May-Jun;7(3):203-6.
Langerhans cells can be induced to migrate into draining lymph nodes after topical application of antigen. During this migration the cells undergo phenotypical changes which are directly related to the function they exert at the different locations. Here the results of kinetic studies as well as phenotypic characterization of Langerhans cells during migration are described and discussed in view of the apparent differences between Langerhans cells in the skin and dendritic cells in lymph nodes.
在局部应用抗原后，朗格汉斯细胞可被诱导迁移至引流淋巴结。在迁移过程中，这些细胞会发生表型变化，这些变化与它们在不同位置发挥的功能直接相关。鉴于皮肤中的朗格汉斯细胞与淋巴结中的树突状细胞之间存在明显差异，本文描述并讨论了朗格汉斯细胞迁移过程中的动力学研究结果以及表型特征。
