树突状细胞在人类免疫缺陷病毒感染免疫发病机制中的作用。
Role of dendritic cells in immunopathogenesis of human immunodeficiency virus infection.
作者信息
Weissman D, Fauci A S
机构信息
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1576, USA.
出版信息
Clin Microbiol Rev. 1997 Apr;10(2):358-67. doi: 10.1128/CMR.10.2.358.
Abstract
The role of dendritic cells (DC) in the pathogenesis of human immunodeficiency virus (HIV) disease has been a subject of considerable interest for several years. Initial studies focused on the infection, dysfunction, and depletion of DC in HIV-infected individuals. More recent studies have begun to identify the functional role of DC in the initiation and propagation of viral replication in T cells in HIV-infected individuals. This review discusses recent data regarding the role of DC in HIV disease with the aim of delineating basic immunopathogenic principles of infection and the development of therapeutic strategies.
摘要
多年来，树突状细胞（DC）在人类免疫缺陷病毒（HIV）疾病发病机制中的作用一直是备受关注的课题。最初的研究集中在HIV感染个体中DC的感染、功能障碍和耗竭。最近的研究已开始确定DC在HIV感染个体T细胞中病毒复制起始和传播中的功能作用。本综述讨论了关于DC在HIV疾病中作用的最新数据，目的是阐明感染的基本免疫致病原理及治疗策略的制定。
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