Fignon A, Fetissof F, Calais G, Lemarie E, Colombat P, Lasne-Charpentier D, Lemseffer J, Wurst C, Body G, Lansac J
Département de Gynécologie Obstétrique, Reproduction humaine et Médecine foetale, Hôpital Bretonneau, Tours.
J Gynecol Obstet Biol Reprod (Paris). 1993;22(4):372-8.
Small cell carcinoma of the ovary is a rare histological form which is highly malignant. We have decided to consider this as an epithelial tumour after studying it with the optical and the electron microscope. It is however difficult to put it in to a definite type because it is highly undifferentiated. On the clinical level small cell carcinoma is different from other ovarian cancers in several respects. Whereas ovarian tumours usually tend to occur in menopausal women in the fifth or sixth decade of life, small cell carcinomas of the ovary occur mainly in younger women of ages between 10 and 38 years. Furthermore, women who are attacked by this kind of a carcinoma tend to die very soon after the diagnosis has been made without receiving any benefit from the many therapies that have been tried to improve the prognosis. We have studied the condition after seeing two cases of small cell carcinoma in the University Gynaecological Department of Tours, and we have made a study of the literature. We have studied the therapeutic angle for these tumours and we have tried to find out what the best technique will be to cope with this awful prognosis. We discuss whether it might be worthwhile in future to intensify therapy in combination with bone marrow autotransplantation.
卵巢小细胞癌是一种罕见的组织学类型，恶性程度很高。在通过光学显微镜和电子显微镜对其进行研究后，我们决定将其视为上皮性肿瘤。然而，由于其高度未分化，很难将其归入某一确定类型。在临床层面，小细胞癌在几个方面与其他卵巢癌不同。卵巢肿瘤通常倾向于发生在50或60岁的绝经后女性中，而卵巢小细胞癌主要发生在年龄在10至38岁的年轻女性中。此外，罹患这种癌症的女性在确诊后往往很快死亡，尽管尝试了多种改善预后的治疗方法，她们却并未从中受益。我们在图尔大学妇科看到两例小细胞癌病例后对这种情况进行了研究，并查阅了相关文献。我们研究了这些肿瘤的治疗角度，并试图找出应对这种糟糕预后的最佳技术。我们讨论了未来强化治疗联合自体骨髓移植是否值得。
