Tennvall J, Johansson L, Albertsson M
Department of Oncology, University Hospital, Lund, Sweden.
Eur J Surg Oncol. 1990 Apr;16(2):109-15.
Primary small cell carcinoma of the oesophagus (SCCO), histologically indistinguishable from its counterpart of the lung, is a rare tumour. Less than 100 cases are reported. A review of 558 consecutive patients with oesophageal carcinomas referred to our department revealed seven cases. These were studied and compared to a survey of 80 cases collected from 24 reports. The present results, as well as the survey, indicate a poor prognosis with rapid and widespread dissemination, and that death is attributed to distant metastases rather than local failure. Freedom from local symptoms was achieved in all seven patients, regardless of therapy modalities employed. A complete response of the primary lesion was observed in three patients after chemo- and subsequent radiotherapy. According to these findings the most suitable treatment approach seems to be the same as for small cell carcinoma of the lung. A detailed immunohistochemical analysis revealed more characteristics similar to small cell carcinoma of the lung than that of the skin, viz 'Merkel cell carcinoma'.
原发性食管小细胞癌（SCCO）在组织学上与其肺部对应物无法区分，是一种罕见肿瘤。报告的病例少于100例。对转诊至我科的558例连续食管癌患者进行回顾，发现7例。对这些病例进行了研究，并与从24篇报告中收集的80例病例调查进行了比较。目前的结果以及该调查表明，预后较差，肿瘤迅速广泛播散，死亡归因于远处转移而非局部衰竭。无论采用何种治疗方式，所有7例患者均未出现局部症状。3例患者在化疗及后续放疗后，原发灶完全缓解。根据这些发现，最合适的治疗方法似乎与肺癌小细胞癌相同。详细的免疫组化分析显示，与皮肤的“ Merkel细胞癌”相比，其与肺癌小细胞癌的相似特征更多。
