Nussler A K, Billiar T R
Department of Surgery, University of Pittsburgh, Pennsylvania 15261.
J Leukoc Biol. 1993 Aug;54(2):171-8.
Nitric oxide (NO), the molecule of the year 1992, is gaining recognition as an important biological mediator. Its multitude of physiologic and pathophysiologic functions result from both a wide distribution of synthesis and diverse mechanisms of action. Besides its functions as a potent vasodilator and neurotransmitter, NO is important in inflammation and immunity. Both beneficial and detrimental consequences of induced synthesis have been discovered. Information is now accumulating on the regulation and function of induced NO. The recent cloning of human inducible NO cDNA should assist in defining the role of inducible NO in human physiology and pathophysiology.
一氧化氮（NO），1992年的“年度分子”，正逐渐被公认为一种重要的生物介质。它众多的生理和病理生理功能源于合成的广泛分布和多样的作用机制。除了作为一种强效血管舒张剂和神经递质的功能外，NO在炎症和免疫中也很重要。诱导合成的有益和有害后果都已被发现。目前关于诱导型NO的调节和功能的信息正在积累。人类诱导型NO cDNA的近期克隆应有助于确定诱导型NO在人类生理和病理生理中的作用。
