二氧化碳激光锥切术后子宫颈的免疫组织化学研究。
Immunohistochemical studies of the uterine cervix after CO2 laser conization.
作者信息
Miyako J, Iwanari O, Kitao M
机构信息
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
出版信息
Int J Gynaecol Obstet. 1993 Jul;42(1):9-13. doi: 10.1016/0020-7292(93)90438-3.
OBJECTIVE
To investigate the process of the maturation of cervical epithelium after CO2 laser conization.
METHOD
Specimens from the uterine cervix (248) resected from 31 premenopausal females who had hysterectomy after CO2 laser conization were studied with 2 kinds of anti-keratin monoclonal antibodies (PKK-1, KL-1).
RESULT
(i) The epithelium covered stroma after 4-6 weeks. (ii) In the normal S-C junction, KL-1 was localized to the middle and upper layers, and PKK-1 to the basal layer. (iii) The staining patterns of KL-1 and PKK-1 in the S-C junctions after conization could be classified into 4 groups according to localization and staining intensity. (iv) The S-C junction appeared normal in all specimens 7 weeks after conization.
CONCLUSION
The regenerating epithelium covered the stroma within 4-6 weeks, but resolution of squamous epithelial metaplasia only occurred 7 weeks after conization.
目的
研究二氧化碳激光锥切术后宫颈上皮的成熟过程。
方法
对31例绝经前女性在二氧化碳激光锥切术后行子宫切除的248份宫颈标本，采用2种抗角蛋白单克隆抗体（PKK - 1、KL - 1）进行研究。
结果
（i）4 - 6周后上皮覆盖间质。（ii）在正常鳞柱交界区，KL - 1定位于中层和上层，PKK - 1定位于基底层。（iii）锥切术后鳞柱交界区KL - 1和PKK - 1的染色模式根据定位和染色强度可分为4组。（iv）锥切术后7周所有标本的鳞柱交界区均表现正常。
结论
再生上皮在4 - 6周内覆盖间质，但鳞状上皮化生的消退仅在锥切术后7周出现。
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