Matsui T, Sinyama H, Asano T
Department of Neurosurgery, Saitama Medical Center/School, Japan.
Neurosurgery. 1993 Aug;33(2):293-300; comment 300. doi: 10.1227/00006123-199308000-00017.
This study compared the therapeutical effect of the prolonged administration of albumin, 2 g/kg body weight per day, with that of saline or dextran, 0.8 g/kg body weight per day, on cerebral ischemia, using an occlusion of the middle cerebral artery in the rat. Brain water, sodium, and potassium contents were measured 72 hours after middle cerebral artery occlusion. The volume of infarction was represented as volume index, which is a total of the infarction area measured in the five brain slices at 168 hours after middle cerebral artery occlusion. The postischemic administration of albumin at the dose tested elucidated an antiedema effect and reduced the infarction size after regional ischemia in rats. These results strongly support the idea that hemodilution therapy with colloids such as albumin has wide usage as a treatment of patients with ischemic cerebral stroke.
本研究采用大鼠大脑中动脉闭塞模型，比较了每天按2 g/kg体重持续输注白蛋白与每天按0.8 g/kg体重输注生理盐水或右旋糖酐对脑缺血的治疗效果。在大脑中动脉闭塞72小时后测量脑内水、钠和钾的含量。梗死体积用体积指数表示，即大脑中动脉闭塞168小时后在五张脑切片上测量的梗死面积总和。以测试剂量进行的缺血后白蛋白给药显示出抗水肿作用，并减小了大鼠局部缺血后的梗死面积。这些结果有力地支持了如下观点：用白蛋白等胶体进行血液稀释疗法在缺血性脑卒患者的治疗中有广泛应用。
