牛分枝杆菌卡介苗64 kDa表面蛋白与不同的小鼠肿瘤细胞存在抗原共享，且在免疫小鼠中具有抗肿瘤活性。

The Mycobacterium bovis BCG 64-kDa surface protein is antigenically shared with different mouse tumor cells and has anti-tumor activity in immunized mice.

作者信息

Ahsan C R, Sasaki J

机构信息

Department of Bacteriology, Hirosaki University School of Medicine, Japan.

出版信息

Immunol Lett. 1993 Jun;36(3):235-8. doi: 10.1016/0165-2478(93)90094-i.

DOI:10.1016/0165-2478(93)90094-i

PMID:7690342

Abstract

The Mycobacterium bovis BCG 64-kDa surface protein, which was found to share antigenic determinants with line 10 hepatoma cells and showed anti-line 10 tumor activity in immunized guinea pigs, has also been found to share common antigenic determinants with Meth A, CT-26 and RL female 1 mouse tumor cells. The 64-kDa protein also demonstrated anti-tumor activity in immunized mice and 37% of the animals challenged with Meth A tumor cells and 50% of those challenged with CT-26 tumor cells completely rejected further tumor growth in the immunized mice. All these data clearly suggest that BCG 64 kDa protein is probably identical with the tumor specific antigen.

摘要

牛分枝杆菌卡介苗（Mycobacterium bovis BCG）的64 kDa表面蛋白，被发现与10号线肝癌细胞具有共同抗原决定簇，且在免疫的豚鼠中显示出抗10号线肿瘤活性，同时也被发现与Meth A、CT - 26和RL雌性1小鼠肿瘤细胞具有共同抗原决定簇。该64 kDa蛋白在免疫的小鼠中也表现出抗肿瘤活性，用Meth A肿瘤细胞攻击的动物中有37%、用CT - 26肿瘤细胞攻击的动物中有50%在免疫小鼠中完全抑制了肿瘤的进一步生长。所有这些数据清楚地表明，卡介苗64 kDa蛋白可能与肿瘤特异性抗原相同。