来自卡介苗的一种64千道尔顿蛋白与10号线肝癌细胞具有相同的抗原决定簇，并具有抗10号线肿瘤活性。
A 64 kDa protein from Mycobacterium bovis BCG shares the same antigenic determinants with line 10 hepatoma cells and has anti-line 10 tumor activity.
作者信息
Ahsan C R, Sasaki J
机构信息
Department of Bacteriology, Hirosaki University School of Medicine, Japan.
出版信息
FEBS Lett. 1991 Aug 19;288(1-2):77-80. doi: 10.1016/0014-5793(91)81006-t.
PMID:1715293
Abstract
A 64 kilodalton (kDa) surface protein was isolated from the water-extracted materials from Mycobacterium bovis strain BCG, the determinants of which are antigenically shared by a 64 kDa major surface antigenic component of line 10 hepatoma cells. The 64 kDa protein showed anti-line 10 tumor activity in pre-immunized guinea pigs, and this suggest that the BCG 64 kDa protein is probably identical with the tumor specific antigen.
摘要
从牛分枝杆菌卡介苗株的水提取物中分离出一种64千道尔顿（kDa）的表面蛋白，其决定簇与10号线肝癌细胞的一种64 kDa主要表面抗原成分具有共同抗原性。该64 kDa蛋白在预先免疫的豚鼠中显示出抗10号线肿瘤活性，这表明卡介苗64 kDa蛋白可能与肿瘤特异性抗原相同。
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