Lau Y L, Chow C B, Lee A C, Ng K W, Lim W L, Chan C F, Lam S Y, Li C K
Department of Paediatrics, University of Hong Kong, Queen Mary Hospital.
Bone Marrow Transplant. 1993;12 Suppl 1:26-8.
Thirty-four of 99 multiply transfused Chinese (49 females, 50 males) with thalassaemia major were positive for antibody to hepatitis C virus. There was no sex predominance in seropositivity with 18 females and 16 males positive. The mean (+/- SD) age and units of blood transfused were significantly higher in the seropositive patients (167 +/- 48 months, 206 +/- 82 units respectively) than the seronegative patients (113 +/- 56 months, 124 +/- 80 units respectively). The seropositive patients had higher mean (+/- SD) serum alanine aminotransferase, aspartate aminotransferase and ferritin concentrations (91 +/- 82 IU/L, 67 +/- 38 IU/L, 4797 +/- 2522 ng/ml respectively) than the seronegative patients (38 +/- 29 IU/L, 48 +/- 28 IU/L, 3620 +/- 2140 ng/ml respectively). Serum ferritin had an independent and significant effect on serum alanine aminotransferase in addition to that of seropositivity to hepatitis C virus.
在99例重度地中海贫血的多次输血的中国患者（49名女性，50名男性）中，34例丙肝病毒抗体呈阳性。血清阳性方面不存在性别优势，18名女性和16名男性呈阳性。血清阳性患者的平均（±标准差）年龄和输血量显著高于血清阴性患者（分别为167±48个月，206±82单位）（血清阴性患者分别为113±56个月，124±80单位）。血清阳性患者的平均（±标准差）血清谷丙转氨酶、谷草转氨酶和铁蛋白浓度（分别为91±82 IU/L，67±38 IU/L，4797±2522 ng/ml）高于血清阴性患者（分别为38±29 IU/L，48±28 IU/L，3620±2140 ng/ml）。除了丙肝病毒血清阳性外，血清铁蛋白对血清谷丙转氨酶有独立且显著的影响。
