Sarbia M, Borchard F, Hengels K J
Department of Pathology, Faculty of Medicine, Heinrich-Heine-University, Düsseldorf, FRG.
Pathol Res Pract. 1993 Jun;189(5):530-5. doi: 10.1016/s0344-0338(11)80361-4.
The presence of Pepsinogen II (PG II), gastral mucin (2B5), CA 19-9, BW 494 and Cytokeratin 20 (CK 20) was investigated in 69 adenocarcinomas of the esophagogastric junction (15 carcinomas in Barrett's esophagus, 9 distal esophageal carcinomas, 31 carcinomas of the cardia and 14 subcardial carcinomas). Evidence of gastric differentiation (expression of Pepsinogen II and/or gastric mucin) was found in more than 50% of the Barrett's carcinomas and the carcinomas of the cardia, but only in 20% of the subcardial carcinomas. High rates of antigen expression were found for the "intestinal" markers CA 19-9 (between 55.5% and 100%) and BW 494 (between 42.9 and 86.7%). CK-20 expression was detected to a significantly higher degree in Barrett's carcinomas (73.3%) than in the other groups (between 29% and 44.4%). These data indicate that the distribution of adenocarcinomas with gastric and/or intestinal differentiation at the esophagogastric junction forms a continuum without clear-cut borders.
在69例食管胃交界腺癌（15例巴雷特食管腺癌、9例远端食管癌、31例贲门癌和14例心下癌）中研究了胃蛋白酶原II（PG II）、胃黏蛋白（2B5）、CA 19-9、BW 494和细胞角蛋白20（CK 20）的存在情况。在超过50%的巴雷特食管癌和贲门癌中发现了胃分化的证据（胃蛋白酶原II和/或胃黏蛋白的表达），但在心下癌中仅为20%。“肠型”标志物CA 19-9（55.5%至100%）和BW 494（42.9%至86.7%）的抗原表达率较高。CK-20在巴雷特食管癌中的表达程度（73.3%）显著高于其他组（29%至44.4%）。这些数据表明，食管胃交界处具有胃和/或肠分化的腺癌分布形成了一个没有明确边界的连续体。
