Via C S, Handwerger B S
Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, 21201.
Curr Opin Rheumatol. 1993 Sep;5(5):570-4. doi: 10.1097/00002281-199305050-00004.
The process of autoantibody production in systemic lupus erythematosus is characterized by findings of both an antigen-driven response and polyclonal B-cell activation. Autoantibody production does not appear to be critically dependent on the presence of the CD5+ B cell subset. Increasing evidence supports a role for T helper cell type 2 cytokines, such as interleukin-4 and interleukin-6, in promoting and perpetuating B-cell hyperactivity and autoantibody formation.
系统性红斑狼疮中自身抗体产生的过程具有抗原驱动反应和多克隆B细胞激活的特征。自身抗体的产生似乎并不严格依赖于CD5+B细胞亚群的存在。越来越多的证据支持2型辅助性T细胞细胞因子，如白细胞介素-4和白细胞介素-6，在促进和维持B细胞过度活跃及自身抗体形成中发挥作用。
