Via C S, Handwerger B S
University of Maryland School of Medicine, Baltimore.
Curr Opin Rheumatol. 1992 Oct;4(5):630-4.
B-cell hyperactivity is characteristic of lupus and appears to be, in many instances, T-cell driven. Recent work continues to examine the paradox of T-cell activation in vivo and depressed T-cell function in vitro. The role of intrinsic B-cell abnormalities, particularly in CD5+ B cells, is an area of active investigation.
B细胞功能亢进是狼疮的特征，在许多情况下似乎是由T细胞驱动的。最近的研究继续探讨体内T细胞活化与体外T细胞功能受抑制这一矛盾现象。内在B细胞异常的作用，尤其是CD5+B细胞中的异常，是一个正在积极研究的领域。
