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p53基因突变在日本前列腺癌肿瘤发生中少见。

Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.

作者信息

Uchida T, Wada C, Shitara T, Egawa S, Koshiba K

机构信息

Department of Urology, Kitasato University School of Medicine, Kanagawa, Japan.

出版信息

Br J Cancer. 1993 Oct;68(4):751-5. doi: 10.1038/bjc.1993.423.

DOI:10.1038/bjc.1993.423
PMID:7691145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1968625/
Abstract

A study was made of the incidence of p53 mutations in Japanese males with prostate cancer or benign prostatic hyperplasia. Polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) was used as a primary screening technique with gene sequencing being carried out in positive cases. Two out of 21 prostate cancers (9.5%) were found to have p53 mutations. These were stage B2 and D2 prostate cancers. No abnormalities were found in the remaining cases or benign prostatic hyperplasia. Mutations of the p53 gene would thus appear infrequent in the tumourigenesis of primary prostate cancer.

摘要

对患有前列腺癌或良性前列腺增生的日本男性中p53基因突变的发生率进行了一项研究。聚合酶链反应单链构象多态性（PCR-SSCP）被用作主要筛查技术，对阳性病例进行基因测序。21例前列腺癌中有2例（9.5%）被发现有p53基因突变。这些是B2期和D2期前列腺癌。其余病例或良性前列腺增生未发现异常。因此，p53基因的突变在原发性前列腺癌的肿瘤发生中似乎不常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/1968625/f8f0fe5fed95/brjcancer00200-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/1968625/d7a159c94843/brjcancer00200-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/1968625/77f41f8bee4c/brjcancer00200-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/1968625/f8f0fe5fed95/brjcancer00200-0110-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/1968625/d7a159c94843/brjcancer00200-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/1968625/77f41f8bee4c/brjcancer00200-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/1968625/f8f0fe5fed95/brjcancer00200-0110-a.jpg

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