Isenberg D, Spellerberg M, Williams W, Griffiths M, Stevenson F
Department of Rheumatology Research, University College London Medical School.
Br J Rheumatol. 1993 Oct;32(10):876-82. doi: 10.1093/rheumatology/32.10.876.
An idiotope designated 9G4 (9G4Id) is known to be a marker for immunoglobulins which utilize a particular VH gene, VH4-21. The idiotope has been found to be present on anti-DNA antibodies, and have been identified in 45% of sera from patients with SLE. This idiotope is strongly associated with lupus being very uncommon amongst the other autoimmune rheumatic diseases tested. This distinction is unlike virtually any of the other DNA antibody idiotypes described which are much more widely distributed. 9G4Id levels were found to fluctuate with disease activity in some lupus patients and this idiotope was detected in 3/11 SLE renal biopsies tested. Its presence is associated with the HLA markers A1 and B8 and raised 9G4Id levels are not simply a reflection of hypergammaglobulinaemia. Thus a new DNA antibody associated idiotope has been identified. Expression of the idiotope indicates that a notable proportion of anti-DNA antibodies have VH segments encoded by the same, or closely related genes, and that these restricted immunoglobulins are involved in the renal pathology found in SLE.
一种名为9G4（9G4Id）的独特型已知是利用特定VH基因VH4-21的免疫球蛋白的标志物。已发现该独特型存在于抗DNA抗体上，并在45%的系统性红斑狼疮（SLE）患者血清中被鉴定出来。这种独特型与狼疮密切相关，在其他接受检测的自身免疫性风湿疾病中非常罕见。这种区别与几乎所有其他已描述的DNA抗体独特型不同，后者分布更为广泛。在一些狼疮患者中，发现9G4Id水平随疾病活动而波动，并且在11份接受检测的SLE肾活检样本中有3份检测到了这种独特型。它的存在与HLA标志物A1和B8相关，9G4Id水平升高并非仅仅是高球蛋白血症的反映。因此，一种新的与DNA抗体相关的独特型已被鉴定出来。该独特型的表达表明，相当一部分抗DNA抗体具有由相同或密切相关基因编码的VH片段，并且这些受限的免疫球蛋白参与了SLE患者的肾脏病理过程。
